- D.Phil thesis
Erythropoietin (Epo) is a circulating hormone which regulates red blood cell production, and hence oxygen-carrying capacity. Three striking features of Epo gene expression are that it shows high level induction in response to hypoxia, that it is tightly tissue-restricted and that it is deficient in most forms of renal damage. Each of these aspects has been investigated in this thesis.
Chapter 3 concerns the hypoxic-sensing system which induces Epo gene expression via an enhancer el...Expand abstract
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- University of Oxford
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- Maxwell, P.H.
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- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
Regulation of the erythropoietin gene
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