- Subtitle:
- D.Phil thesis
- Abstract:
-
Erythropoietin (Epo) is a circulating hormone which regulates red blood cell production, and hence oxygen-carrying capacity. Three striking features of Epo gene expression are that it shows high level induction in response to hypoxia, that it is tightly tissue-restricted and that it is deficient in most forms of renal damage. Each of these aspects has been investigated in this thesis.
Chapter 3 concerns the hypoxic-sensing system which induces Epo gene expression via an enhancer el...
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- Publication date:
- 1994
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- URN:
-
uuid:86a152eb-cfc8-4812-935e-c89ab48acee3
- Local pid:
- td:603832170
- Language:
- English
- Copyright holder:
- Maxwell, P.H.
- Copyright date:
- 1994
- Notes:
- The digital copy of this thesis has been made available thanks to the generosity of Dr Leonard Polonsky
Thesis
Regulation of the erythropoietin gene
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