Structural, biophysical and cellular analysis of synaptic receptors and organizers

Thesis

Synapse formation, differentiation and plasticity involve modulation of pre- and post-synaptic elements. During synaptogenesis synaptic compartments differentiate in response to molecular cues. Once contact is made, both dendritic and axonal cells undergo further morphological changes resulting in the formation of a synapse which then matures in response to activity. The α-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) receptors are responsible for fast excitatory neurotransmi...

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Authors: Clayton, AJ

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: MDGA; AMPA receptor; neuronal pentraxin; TARP
• Subjects: Biochemistry; Neuroscience; Crystallography; Life Sciences; Molecular biophysics (biochemistry); Physical Sciences