Identifying causal mechanisms for beta cell dysfunction at type 2 diabetes risk loci

Thesis

Genome-wide association studies (GWAS) have identified more than 150 loci associated with type 2 diabetes (T2D) risk. Most association signals are located in noncoding regions of the genome, and uncertainty remains over the causal gene in the vast majority of cases. Motivated by the overall aim of accelerating the translation of genetic discoveries into molecular mechanisms for disease pathogenesis, the work presented in this thesis sought to identify candidate causal genes, and to study ...

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Authors: Thomsen, S

• DOI: 10.5287/ora-qq45byojg
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English