Thesis icon

Thesis

Defining antibiotic treatment duration and its impact on antimicrobial resistance

Abstract:

Reducing antibiotic treatment duration is a key stewardship intervention to mitigate antimicrobial resistance. In this thesis, I first address methodological issues introduced by non-adherence in non-inferiority trials, the commonest design for antibiotic duration randomised controlled trials. I conducted a simulation study and found that the probability of concluding non-inferiority when the treatment efficacy is actually inferior can be increased to as high as 0.1 from the acceptable 0.05 w...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
NDM
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
More from this funder
Name:
National Medical Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100001349
Grant:
NMRC/Fellowship/0051/2017
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Deposit date:
2022-03-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP