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Developing biophysical and structural methods for characterisation of small molecule modulators of K2P potassium channels

Abstract:

Biophysical techniques are widely used to determine the structure, function and ligand binding properties of a protein. However, their application to membrane proteins has been limited due to the difficulty of obtaining sufficient purified sample.

In this work, I use such methods to examine the thermostability and ligand binding properties of TREKs, two members of the family of tandem pore domain K+ channels important for the regulation of cellular excitability. Structur...

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Division:
MSD
Role:
Author

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Supervisor
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Supervisor
Department:
Pfizer
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:850d137b-6270-48d9-9eaa-ce6fb65dcbc4
Deposit date:
2018-04-18

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