Thesis icon

Thesis

Human orthologues of Saccharomyces cerevisiae Trf4/5 non-canonical poly(A) polymerases

Abstract:

RNA waste in the budding yeast nucleus is degraded 3’-5’ via exosome-mediated pathways associated with the non-canonical poly(A) polymerases Trf4 and Trf5. Multiple sequence alignments identify POLS and PAPD5 as the human orthologues of Trf4 and Trf5. This research has investigated the degree of conservation and extent of divergence of POLS and PAPD5 from their orthologues. Mass spectrometric analysis identified interacting protein partners of POLS that are mostly nuclear and are associated w...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Oxford college:
Queen's College, The
Department:
Medical Sciences Division
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:84adcce5-c6cc-4876-b4d4-0b1a94176001
Local pid:
ora:6679

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP