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Thesis

Probing the mechanisms underlying the modulation of dopamine release by axonal cholinergic inputs in mice and Drosophila

Abstract:

Mesostriatal dopamine (DA) transmission plays key roles in the functions of the basal ganglia such as reward prediction signalling and regulation of goal-directed behaviour. Dysregulation of DA release is implicated in numerous neurological and psychiatric disorders such as Parkinson’s disease and addiction. DA signalling, in addition to being driven through action potential (AP) generated at the cell body, can be gated locally by neuromodulators present within the striatum. Elucidation of...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Role:
Supervisor
ORCID:
0000-0001-9677-2256
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy and Genetics
Role:
Supervisor

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Funder identifier:
https://ror.org/052gg0110

DOI:
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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