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Thesis

Phenotypic models of T cell activation

Abstract:

T cells are important immune cells that initiate and regulate immune responses to cell surface antigens. The productive binding of T cell receptors (TCRs) to cell surface antigens initiates a signal transduction cascade within the T cell that results in T cell effector functions. It is established that the dose of antigen and the binding parameters between TCRs and antigen determines the functional response of the T cell. Although much progress has been made to identify the molecules ...

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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