Thesis icon

Thesis

Development of spontaneous isopeptide bond formation for ligation of peptide tags

Abstract:

Peptide tags are ubiquitous in the life sciences, with roles including purification and selective labeling of proteins. Because peptide tags are small they have a limited surface area for binding and hence usually form low affinity protein interactions. These weak interactions limit the uses of peptide tags in cases that require resistance to forces generated with macromolecular architectures or protein motors. Hence a way to create a covalent interaction with a peptide tag would be useful...

Expand abstract

Actions


Authors


More by this author
Institution:
University of Oxford
Research group:
Dr. Mark Howarth
Oxford college:
New College
Department:
Medical Sciences Division - Biochemistry
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:833289ee-87cf-42f0-a66f-ca9ef9dd6420
Local pid:
ora:8875

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP