Thesis
Striatal neuromodulation of serotonin transmission in health and a mouse model of early Parkinsonism
- Abstract:
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The striatum receives dense dopaminergic (DA) input from the midbrain and sparser serotonergic (5-hydroxytryptamine, 5-HT) input from the raphe nuclei. While striatal 5-HT is known to interact with DA signalling and regulate striatal output, the mechanisms underlying 5- HT release regulation have remained poorly understood, in part due to technical limitations. In this thesis, I used a genetically encoded G-protein-coupled receptor sensor (GRAB5-HT3.0; Deng et al., 2024) to investigate how st...
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- Files:
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(Preview, Dissemination version, pdf, 72.1MB, Terms of use)
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Authors
Contributors
+ Cragg, S
- Institution:
- University of Oxford
- Division:
- MSD
- Role:
- Supervisor
- ORCID:
- 0000-0001-9677-2256
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Deposit date:
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2025-12-20
- ARK identifier:
Terms of use
- Copyright holder:
- Qinbo Qiao
- Copyright date:
- 2025
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