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Thesis

Dissecting mechanisms involved in the aetiological overlap between Type 2 diabetes and cancer

Alternative title:
Type 2 diabetes and cancer
Abstract:

The advent of large scale genome wide association studies (GWAS) have uncovered a plethora of proposed susceptibility loci, most previously not connected to T2D pathogenesis. One of the most intriguing GWAS discoveries is the frequency with which T2D susceptibility loci map close to genes with roles in cell-cycle regulation. This previously unsuspected link between genes known for being dysregulated in cancer and T2D pathogenesis is supported by epidemiological evidence linking T2D and can...

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Division:
MSD
Department:
NDM
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:8292ba96-d38e-4d45-9489-06191beaf107
Deposit date:
2016-10-27

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