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Thesis

Investigation of CD27-CD70 co-stimulation in human regulatory T cells for enhanced cellular therapy in transplantation

Abstract:

CD4+FOXP3+ regulatory T cells (Tregs) are essential for maintaining immune homeostasis and are a focus of investigation in the treatment of transplant rejection and autoimmune diseases. Current clinical protocols for Treg cellular therapy production are heavily reliant on in vitro expansion techniques. However, post-expansion Tregs demonstrate heterogeneity with some subpopulations displaying unstable regulatory phenotype and function. The aim of this study was to investigate this phenomen...

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Role:
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Role:
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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