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Thesis

A phase II randomised controlled trial of amiloride as a neuroprotective treatment in optic neuritis – studying in vivo neurodegeneration, neuroprotection and cortical plasticity after an inflammatory insult to the visual system

Abstract:

Basic science and early clinical trial evidence suggest the safe diuretic drug amiloride, may exert a neuroprotective effect in multiple sclerosis (MS) through blockade of the acid sensing ion channel. Neuroprotective treatments are a key unmet need in multiple sclerosis. Optic neuritis (ON) is a discrete CNS inflammatory event leading to neuro­axonal injury in the optic nerve and retina.

The optic nerve is part of the visual system, one of the most functionally and structurally el...

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Division:
MSD
Department:
University of Oxford
Role:
Author

Contributors

Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor

Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:824ca36c-68ed-4b0c-90dc-925941ce9450
Deposit date:
2018-04-20

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