Thesis
A phase II randomised controlled trial of amiloride as a neuroprotective treatment in optic neuritis – studying in vivo neurodegeneration, neuroprotection and cortical plasticity after an inflammatory insult to the visual system
- Abstract:
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Basic science and early clinical trial evidence suggest the safe diuretic drug amiloride, may exert a neuroprotective effect in multiple sclerosis (MS) through blockade of the acid sensing ion channel. Neuroprotective treatments are a key unmet need in multiple sclerosis. Optic neuritis (ON) is a discrete CNS inflammatory event leading to neuroaxonal injury in the optic nerve and retina.
The optic nerve is part of the visual system, one of the most functionally and structurally el...
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- Files:
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(Preview, Dissemination version, pdf, 19.6MB, Terms of use)
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Authors
Contributors
+ Craner, M
- Department:
- Nuffield Department of Clinical Neurosciences
- Role:
- Supervisor
+ Palace, J
- Department:
- Nuffield Department of Clinical Neurosciences
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- UUID:
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uuid:824ca36c-68ed-4b0c-90dc-925941ce9450
- Deposit date:
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2018-04-20
- ARK identifier:
Terms of use
- Copyright holder:
- McKee, J
- Copyright date:
- 2017
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