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Thesis

A phase II randomised controlled trial of amiloride as a neuroprotective treatment in optic neuritis – studying in vivo neurodegeneration, neuroprotection and cortical plasticity after an inflammatory insult to the visual system

Abstract:

Basic science and early clinical trial evidence suggest the safe diuretic drug amiloride, may exert a neuroprotective effect in multiple sclerosis (MS) through blockade of the acid sensing ion channel. Neuroprotective treatments are a key unmet need in multiple sclerosis. Optic neuritis (ON) is a discrete CNS inflammatory event leading to neuro­axonal injury in the optic nerve and retina.

The optic nerve is part of the visual system, one of the most functionally and structurally el...

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Department:
University of Oxford

Contributors

Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
Department:
Nuffield Department of Clinical Neurosciences
Role:
Supervisor
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Grant:
952/11
Funding agency for:
Project
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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