Thesis
Understanding the role of amyloid beta and tau protein in neuronal vulnerability in models of sporadic Alzheimer’s disease
- Abstract:
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Alzheimer's disease (AD) is a neurodegenerative disease, and it is the most common form of dementia. AD is characterised by two main pathological hallmarks: the accumulation of extracellular plaques, composed mainly of amyloid beta (A$\beta$), and of intracellular neurofibrillary tangles (NFTs) containing mostly hyperphosphorylated tau aggregates. Most animal and cellular models to date have focused on fAD, and recapitulate some key pathological features of AD. However, sporadic AD (sAD) mode...
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- Files:
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(Preview, Dissemination version, pdf, 154.9MB, Terms of use)
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Authors
Contributors
+ Jolly, H
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Centre for Human Genetics
- Research group:
- Fowler Group
- Role:
- Contributor
- ORCID:
- 0009-0006-5411-2392
+ Vallin, B
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Contributor
+ Hedegaard, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pathology Dunn School
- Role:
- Contributor
- ORCID:
- 0000-0003-1536-896X
+ Ng, B
- Institution:
- A*STAR Institute of Molecular and Cell Biology
- Role:
- Contributor
+ Wade-Martins, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Oxford college:
- Christ Church
- Role:
- Supervisor
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2026-08-24
- ARK identifier:
Terms of use
- Copyright holder:
- Féodora Louise Bertherat
- Copyright date:
- 2025
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