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Functional evaluation of smad4 disruption in mouse intestinal adenoma

Abstract:

Human colorectal cancer (CRC) is one of the most common types of cancer. Aberrant activation of the Wnt pathway, typically via adenomatous polyposis coli (Apc) loss of function, acts as the initiating event for adenoma formation. However, alterations in additional pathways are associated with progression towards CRC. For example, 10-15% of carcinomas downregulate the transforming growth factor-β (TGF-β) pathway due to SMAD4 mutations in either the MH1 domain, the linker or th...

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Mirvat Surakhy More by this author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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