Journal article
Defective cholesterol metabolism in amyotrophic lateral sclerosis.
- Abstract:
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As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. More than 40 different sterols were quantified in serum and cerebrospinal fluid (CSF) from ALS patients and healthy controls. In CSF the concentration of cholesterol was found to be elevated in ALS samples. When CSF met...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 746.8KB)
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(Accepted manuscript, pdf, 115.7KB)
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(Accepted manuscript, xlsx, 86.2KB)
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- Publisher copy:
- 10.1194/jlr.P071639
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
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Grant:
BB/L001942/1
BB/I001735/1
Swedish Science Council
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Bibliographic Details
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Lipid Research Journal website
- Publication date:
- 2016-11-03
- Acceptance date:
- 2016-11-01
- DOI:
- ISSN:
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0022-2275 and 1539-7262
- Source identifiers:
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657338
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:657338
- UUID:
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uuid:81477722-0749-4d5f-a1b9-59562bbf223e
- Local pid:
- pubs:657338
- Deposit date:
- 2016-11-08
Terms of use
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.
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