- Abstract:
-
As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. More than 40 different sterols were quantified in serum and cerebrospinal fluid (CSF) from ALS patients and healthy controls. In CSF the concentration of cholesterol was found to be elevated in ALS samples. When CSF met...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(xlsx, 86.2KB)
-
(pdf, 746.8KB)
-
(pdf, 115.7KB)
-
- Publisher copy:
- 10.1194/jlr.P071639
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
- Grant:
- BB/I001735/1; BB/L001942/1
- Publisher:
- American Society for Biochemistry and Molecular Biology Publisher's website
- Journal:
- Journal of Lipid Research Journal website
- Publication date:
- 2016-11-03
- Acceptance date:
- 2016-11-05
- DOI:
- ISSN:
-
0022-2275 and 1539-7262
- Pubs id:
-
pubs:657338
- URN:
-
uri:81477722-0749-4d5f-a1b9-59562bbf223e
- UUID:
-
uuid:81477722-0749-4d5f-a1b9-59562bbf223e
- Local pid:
- pubs:657338
- Copyright holder:
- American Society for Biochemistry and Molecular Biology
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.
Journal article
Defective cholesterol metabolism in amyotrophic lateral sclerosis.
Actions
Access Document
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Swedish Science Council
More from this funder
Expand funders...
Bibliographic Details
Item Description
Terms of use
If you are the owner of this record, you can report an update to it here: Report update to this record