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Journal article

Defective cholesterol metabolism in amyotrophic lateral sclerosis.

Abstract:

As neurons die cholesterol is released in the central nervous system (CNS), hence this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS) in which altered cholesterol levels have been linked to prognosis. More than 40 different sterols were quantified in serum and cerebrospinal fluid (CSF) from ALS patients and healthy controls. In CSF the concentration of cholesterol was found to be elevated in ALS samples. When CSF met...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1194/jlr.P071639

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Swedish Science Council More from this funder
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Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Lipid Research Journal website
Publication date:
2016-11-03
Acceptance date:
2016-11-05
DOI:
ISSN:
0022-2275 and 1539-7262
Pubs id:
pubs:657338
URN:
uri:81477722-0749-4d5f-a1b9-59562bbf223e
UUID:
uuid:81477722-0749-4d5f-a1b9-59562bbf223e
Local pid:
pubs:657338

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