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Thesis

The biological role of DNA modifications deposited over gene bodies

Abstract:

5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are the most common DNA modifications in vertebrate genomes. Promoter-residing 5mC is a well-established transcriptional repression mark. However, the role of gene body DNA modifications, especially those involving 5hmC, remains elusive and controversial. In this study, the role of genic 5mC and 5hmC in transcriptional regulation is investigated. By engineering a cell line with inducible 5hmC it is shown that deposition of 5hmC caus...

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Department:
Ludwig Cancer Research
Role:
Author

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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