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Fibroblast Growth Factor 2 (FGF2) in cartilage injury and repair

Abstract:

Fibroblast Growth Factors (FGFs) are important pleiotropic growth factors with a proven role in joint development and postnatal homeostasis. Previously our group has shown that FGF2 is released upon cartilage injury and Fgf2 knockout (KO) mice develop accelerated osteoarthritis (OA), suggesting it is chondroprotective in vivo. Work from others has shown that the accelerated OA phenotype in the Fgf2 KOs is phenocopied by deletion of Fgfr3 but not Fgfr1, s...

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DARS
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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
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English
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