Thesis icon

Thesis

The role of the transcription factor BRN2 in melanoma

Abstract:

Expression of the POU-domain transcription factor BRN2 is crucial for the developing brain and drives proliferation and invasiveness in cancers of neural crest origin including melanoma. However, our understanding of BRN2 function and how its behaviour is modulated remains incomplete. We therefore aimed to investigate how protein:protein interaction and post-translational modification might influence the activity of BRN2 and how this impacts on melanoma cell phenotype.

We show that,...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Department:
Ludwig Institute for Cancer Research

Contributors

Department:
Ludwig Institute for Cancer Research
Role:
Supervisor
Department:
Department of Oncology
Role:
Supervisor
More from this funder
Grant:
Clinician Research Training Fellowship
Funding agency for:
Katharine Herbert
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP