Investigating the role of the endocannabinoid system and gut-microbiome in psychotic and severe mental illness: a focus on negative symptoms

Thesis

Negative symptoms, such as anhedonia and amotivation, represent unmet therapeutic needs and key determinants of functional loss in severe mental illness. Albeit traditionally considered a unique feature of schizophrenia, anhedonia and amotivation manifest outside the psychotic spectrum, where they are equally debilitating and difficult to treat. A number of clinical trials using newly developed compounds or re-repurposing existing drugs have tried to treat negative symptoms without su...

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Authors: Minichino, A

• DOI: 10.5287/ora-nggjy2rd4
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: psychosis; amotivation; anhedonia; depression; negative symptoms; endocannabinoids; schizophrenia; microbiome
• Subjects: Biological psychiatry