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The role of DNA methylation on transcription factor occupancy and transcriptional activity

Abstract:

DNA methylation is an epigenetic mark that is deposited throughout the genome of mammals and plays an important role in the maintenance of transcriptionally repressive states across cell divisions. There are two major mechanisms by which DNA methylation has been proposed to act: one involves the recognition of the mark by protein complexes containing histone deacetylases (HDACs) that can remodel the local chromatin. Alternatively, methylation has been suggested to directly affect the inter...

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Martin Cusack More by this author

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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