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Thesis

Developing novel blood-stage malaria vaccines

Abstract:

Natural exposure to Plasmodium falciparum’s asexual blood-stage results in protection against severe disease, but no vaccine using the widely-studied blood-stage antigens apical membrane antigen 1 (AMA1) or merozoite surface protein 1 (MSP1) has proven convincingly protective in clinical trials. Challenges include antigenic polymorphism, the apparent requirement for exceptionally high antibody concentrations for protection, and clinical-grade production of conformationally-accurate recombi...

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Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Research group:
Jenner Institute
Oxford college:
Wadham College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
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Funding agency for:
Alexander D Douglas
Publication date:
2015
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:7ca728f5-6b5e-4f59-ae4b-dd81c8d9e2e8
Local pid:
ora:6856

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