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Thesis

The role of interferon-gamma-mediated T cell collectivity on CD8+ T cell responses

Abstract:

Immune responses towards intracellular pathogens and tumours rely on CD8+ T lymphocytes, whose function it is to kill infected or cancer cells, while sparing healthy tissue. CD8+ T cell immune responses are characterized by a remarkable degree of poly-clonality and poly-functionality. However, their overall population response is consistent and robust. Much research has focused on individual T cell activation, but how individual, heterogenous T cell responses are integrated at the populati...

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Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0003-3059-3065
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
ORCID:
0000-0003-4983-6389
More from this funder
Name:
Kennedy Trust for Rheumatology Research
Funder identifier:
http://dx.doi.org/10.13039/100016580
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2023-04-11

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