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Thesis

Design, implementation and experimental validation of a network-based model to predict mitotic microtubule regulating proteins

Abstract:

The purpose of this thesis was to study mitosis in Drosophila, from a network biology perspective. The primary aim was to develop and test a network-based prediction model that could integrate available data in public databases (like Flybase) and, based on that, predict potential mitotic proteins.

The approach taken to design the protein interaction network included the use of a priori knowledge about the microtubule composition of the mitotic spindle and the higher likelihood of mi...

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Institution:
University of Oxford
Division:
MPLS
Department:
Statistics
Research group:
Deane Group
Oxford college:
St Anne's College
Role:
Author

Contributors

Division:
MPLS
Department:
Statistics
Role:
Supervisor
Division:
MPLS
Department:
Statistics
Role:
Supervisor

Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

Language:
English
Keywords:
Subjects:
UUID:
uuid:7c27b09b-08c3-43f5-93c3-0580cf5fd103
Local pid:
ora:8881
Deposit date:
2014-08-18

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