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Thesis

Selective targeting of homologous recombination deficiency

Abstract:

Homologous recombination (HR) is a key DNA repair pathway essential for cell viability. Counter-intuitively, HR deficiency can trigger carcinogenesis. Understanding the mechanisms that allow the rampant proliferation of HR-deficient tumour cells is crucial for the development of improved therapeutic modalities to selectively inhibit the outgrowth of these cells.

Recently, we identified extracellular signal-regulated kinase 1 (ERK1) as a factor required for the proliferation of BRCA2...

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Institution:
University of Oxford
Research group:
Telomeres and Genome Stability Group
Oxford college:
St Cross College
Role:
Author

Contributors

Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Supervisor
Publication date:
2014
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:7c277bdd-a1fa-48f8-91cf-8b1ed78030e1
Local pid:
ora:11406
Deposit date:
2015-05-08

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