Thesis
Using Mendelian randomization and genetic epidemiology strategies to elucidate novel causal biological mechanisms and pathways connecting risk factors with disease outcomes
- Abstract:
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Cardiometabolic diseases, including type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and coronary artery disease (CAD), impose a significant global health burden due to their shared risk factors and complex etiology. Despite advancements in treatment, therapeutic development has been hindered by an incomplete understanding of the shared mechanisms driving these diseases. This thesis leverages advanced genetic methodologies and multi-omics approaches to elucidate disease mecha...
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- Files:
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(Preview, Dissemination version, pdf, 6.2MB, Terms of use)
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(Supplementary materials, zip, 67.3MB, Terms of use)
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Authors
Contributors
+ Davey Smith , G
- Institution:
- University of Bristol
- Role:
- Supervisor
+ Ray , D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Oxford Centre for Diabetes, Endocrinology and Metabolism
- Research group:
- Ray Group
- Oxford college:
- Wolfson College
- Role:
- Supervisor
- ORCID:
- 0000-0002-4739-6773
+ Lohoff , F
- Institution:
- National Institutes of Health
- Role:
- Supervisor
+ Christodoulides, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Sub department:
- RDM-Oxford Centre for Diabetes, Endocrinology and Metabolism
- Oxford college:
- Keble College
- Role:
- Supervisor
+ Preiss, D
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Nuffield Department of Population Health
- Sub department:
- Population Health
- Role:
- Examiner
- ORCID:
- 0000-0003-3139-1836
+ National Institutes of Health (NIH) Oxford–Cambridge Scholars Program
More from this funder
- Funding agency for:
- Rosoff, DB
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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2329000
- Local pid:
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pubs:2329000
- Deposit date:
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2025-11-05
- ARK identifier:
Terms of use
- Copyright holder:
- Daniel B. Rosoff
- Copyright date:
- 2025
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