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Thesis

The role of novel genetic and epigenetic mechanisms in the development of type 2 diabetes

Abstract:

Type 2 diabetes (T2D) is a metabolic disease characterised by insulin resistance and beta-cell failure and a leading cause of mortality and morbidity. GWAS have identified pancreatic beta-cell dysfunction as a major player in T2D pathogenesis, but since the majority of signals reside in non- coding sequence the causal variant(s) and effector transcripts often remain undefined. Combining human genetic discoveries with genomic interrogation of relevant tissues was shown to provide a powerful...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

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Supervisor
Role:
Supervisor
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Funding agency for:
Thurner, M
Grant:
099673/Z/12/Z
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:7ae45a54-45ea-4cdc-9c65-0068adb9ce67
Deposit date:
2017-02-02

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