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Thesis

Functional analysis of mutations in isocitrate dehydrogenase involved in gliomagenesis

Abstract:

The main subject of my thesis is the investigation of mechanisms of glioma tumorigenesis associated with the recently identified mutations in isocitrate dehydrogenase. Gliomas account for 80% of primary brain cancers. They represent a diverse group of tumours, and are graded from I-IV based on histopathological features. Whilst grade I tumours may be curable with surgery alone, grade II and III gliomas inevitably progress to glioblastoma multiforme (GBM), which is highly resistant to curre...

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Institution:
University of Oxford
Research group:
Tomlinson
Oxford college:
Green Templeton College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:79f06454-d126-4fb6-9aa7-6ccf835763d2
Local pid:
ora:11442

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