Molecular pharmacology of native and exogenous vascular ion channels

Thesis

Vascular Ca²⁺-activated chloride channels (CaCCs), are a class of ligand- and voltage-gated channels that couple agonist binding and inositol triphosphate (IP3) signalling to depolarisation of the cell membrane and smooth muscle contraction. The elucidation of the precise physiological role and the pharmacological profile of this channel has been accelerated by the recent discovery of the gene (TMEM16A) coding for these channels. Based on the rationale that depolarising me...

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Authors: Ta, C

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford