Thesis
The cell-intrinsic and microenvironmental basis of impaired B lymphopoiesis in Trisomy 21 fetal bone marrow
- Abstract:
-
Background: Children with Down syndrome, which is caused by trisomy of chromosome 21 (T21), have an increased risk of developing B cell acute lymphoblastic leukaemia (ALL) and an increased frequency and severity of infections. Individuals with Down syndrome also have B lymphopenia and an increased frequency of autoimmune diseases often in association with circulating self-reactive antibodies. Our lab has previously shown this striking reduction in B cell frequency can be trac... Expand abstract
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Authors
Contributors
+ O'Byrne, S
- Role:
- Contributor
+ Murnane, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Radcliffe Department of Medicine
- Role:
- Contributor
- ORCID:
- No
+ Hamer, L
- Role:
- Contributor
- ORCID:
- 0009-0007-1902-4474
+ Roy, A
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Paediatrics
- Role:
- Supervisor
+ Roberts, I
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Paediatrics
- Role:
- Supervisor
- ORCID:
- 0000-0002-6094-6397
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2026-04-12
- ARK identifier:
Terms of use
- Copyright holder:
- Arundhati Wuppalapati
- Copyright date:
- 2025
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