Mechanisms for CpG Island Methylation during X chromosome inactivation

Thesis

During early development in female mammals one of the two X chromosomes is transcriptionally silenced, ensuring an equal dosage of X-linked genes relative to their XY male counterparts. This phenomenon is termed X chromosome inactivation (XCI). XCI is initiated by expression of the long noncoding RNA (lncRNA) Xist from the inactive X chromosome (Xi). Xist orchestrates molecular pathways in cis to establish transcriptional silencing and heterochromatinization of the Xi in a multi- stage pro...

Expand abstract

Authors: Yasmin, K

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• DOI: 10.5287/ora-qqx0ppgor
• Language: English
• Keywords: CGI methylation; DNMT3B; X Chromosome Inactivation; DNA Methylation; CpG Islands
• Subjects: DNA methylation; CGI methylation; High-throughput nucleotide sequencing; Epigenetics; Gene regulation; Gene silencing