Thesis
Exploring metabolic vulnerability and therapeutic potential in cancers with isocitrate dehydrogenase mutations
- Abstract:
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Treatment of mutant isocitrate dehydrogenase 1 (IDH1) glioma remains challenging; targeted allosteric inhibitors currently provide limited clinical effect. Resistance to mutIDH1 inhibitors has also emerged in other cancers with mutant IDH1. IDH1 catalyses the decarboxylation of isocitrate to 2-oxoglutarate (2-OG) and concomitant reduction of NADP+ to NADPH. Upon mutation, the enzyme instead reduces 2-OG to (R)-2-hydroxyglutarate (2 HG) with NADPH. 2 HG accumulates to high levels i...
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- Files:
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(Preview, Dissemination version, pdf, 15.4MB, Terms of use)
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Authors
Contributors
+ McCullagh, J
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Role:
- Supervisor
- ORCID:
- 0000-0003-4733-1205
+ Kawamura, A
- Institution:
- University of Oxford
- Division:
- MPLS
- Department:
- Chemistry
- Role:
- Examiner
+ Ebbels, T
- Role:
- Examiner
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Deposit date:
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2024-05-26
- ARK identifier:
Terms of use
- Copyright holder:
- Hvinden, IC
- Copyright date:
- 2022
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