Thesis
Exploring metabolic vulnerability and therapeutic potential in cancers with isocitrate dehydrogenase mutations
- Abstract:
-
Treatment of mutant isocitrate dehydrogenase 1 (IDH1) glioma remains challenging; targeted allosteric inhibitors currently provide limited clinical effect. Resistance to mutIDH1 inhibitors has also emerged in other cancers with mutant IDH1. IDH1 catalyses the decarboxylation of isocitrate to 2-oxoglutarate (2-OG) and concomitant reduction of NADP+ to NADPH. Upon mutation, the enzyme instead reduces 2-OG to (R)-2-hydroxyglutarate (2 HG) with NADPH. 2 HG accumulates to high levels i...
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Authors
Contributors
+ McCullagh, J
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Supervisor
ORCID:
0000-0003-4733-1205
+ Kawamura, A
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Examiner
+ Ebbels, T
Role:
Examiner
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- DOI:
Item Description
- Language:
-
Englihs
- Keywords:
- Subjects:
- Deposit date:
-
2024-05-26
Related Items
Terms of use
- Copyright holder:
- Hvinden, IC
- Copyright date:
- 2022
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