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Thesis

Cell stress response and hypoxia in breast cancer

Abstract:

During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting in the accumulation of unfolded proteins with consequent endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) and autophagy, a process involved in the physiological turnover of cytoplasmic components. The link between the UPR and autophagy is not clearly defined. The aim of this thesis is to investigate the role of the induction of UPR under severe hypoxia...

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Institution:
University of Oxford
Oxford college:
Green College
Department:
Medical Sciences Division - Molecular Medicine,Weatherall Institute of

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Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:74d3bf91-9888-4e9e-b5e1-7d5d2d476174
Local pid:
ora:6658

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