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Thesis

Mechanistic studies of DNA repair and genome instability

Abstract:

The accurate repair of DNA damage is essential for protecting cells from undergoing cell death or accumulating mutations. The multi-topical work presented within this thesis focuses on the mechanistic study of DNA repair and sources of genome instability.

Interstrand crosslinks (ICLs) are toxic DNA lesions that block the essential cellular processes of transcription and replication. The mechanisms of ICL repair pathways in non-dividing cells are poorly characterized. This study aim...

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Division:
MSD
Department:
NDM
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
ORCID:
0000-0002-8679-4627
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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