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The role of the cytoplasmic domain of the macrophage scavenger receptor MARCO in adhesion and uptake

Abstract:

The macrophage receptor with collagenous structure (MARCO) is a class A scavenger receptor. Class A scavenger receptors are multifunctional type II transmembrane glycoproteins that have roles in modified lipoprotein uptake, innate immunity, and macrophage adhesion. It has been shown that the extracellular cysteine-rich domain of MARCO is important for ligand binding, but the role of the cytoplasmic N-terminal domain has not yet been characterised. The aim of this study was to investigate t...

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Institution:
University of Oxford
Research group:
Professor Siamon Gordon's group
Oxford college:
Lincoln College
Department:
Medical Sciences Division - Pathology
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2008
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
URN:
uuid:715c4542-99bb-4bd5-b1ab-318814aa9eb5
Local pid:
ora:10679

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