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Arming oncolytic viruses with bispecific T cell engagers (BiTEs) for expression and secretion into the tumour microenvironment

Abstract:

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express bispecific single chain antibodies, secreted from infected tumour cells into the microenvironment. The bispecific T cell engager (BiTE) binds to a selected antigen on target cells and crosslinks them to CD3 on T cells, leading to clustering and activation o...

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Joshua Freedman More by this author

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Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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