Thesis icon

Thesis

Arming oncolytic viruses with bispecific T cell engagers (BiTEs) for expression and secretion into the tumour microenvironment

Abstract:

Oncolytic viruses exploit the cancer cell phenotype to complete their lytic life cycle, releasing progeny virus to infect nearby cells and repeat the process. We modified the oncolytic group B adenovirus EnAdenotucirev (EnAd) to express bispecific single chain antibodies, secreted from infected tumour cells into the microenvironment. The bispecific T cell engager (BiTE) binds to a selected antigen on target cells and crosslinks them to CD3 on T cells, leading to clustering and activation o...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Cancer Research UK More from this funder
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:6e23f1c4-81a1-49e0-8e12-f01d629d61c4
Deposit date:
2018-06-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP