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Investigating the regulation and functioning of RNT-1 and BRO-1 in C. elegans

Abstract:

The stem cell-like seam cells of the nematode, Caenorhabditis elegans, represent a tractable and powerful model for studying stem cell biology. rnt-1, the worm homologue of the mammalian RUNX family of transcription factors, together with the CBFβ homologue bro-1, is essential for the proliferation of the seam cells. RUNX genes and CBFβ are important regulators of stem cell development in mammals, and are associated with a variety of cancers. The worm seam cell model offers an opportunity ...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Woollard laboratory
Oxford college:
Magdalen College
Role:
Author

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Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:6d9cd263-1051-443a-b064-c0c329252b28
Local pid:
ora:6784
Deposit date:
2013-03-27

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