Thesis
Investigating the regulation and functioning of RNT-1 and BRO-1 in C. elegans
- Abstract:
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The stem cell-like seam cells of the nematode, Caenorhabditis elegans, represent a tractable and powerful model for studying stem cell biology. rnt-1, the worm homologue of the mammalian RUNX family of transcription factors, together with the CBFβ homologue bro-1, is essential for the proliferation of the seam cells. RUNX genes and CBFβ are important regulators of stem cell development in mammals, and are associated with a variety of cancers. The worm seam cell model offers an opportunity ...
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Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:6d9cd263-1051-443a-b064-c0c329252b28
- Local pid:
- ora:6784
- Deposit date:
- 2013-03-27
Terms of use
- Copyright holder:
- Brabin, C
- Copyright date:
- 2011
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