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Thesis

Identifying biophysical determinants of virus-cell fusion through live-cell imaging

Abstract:

The biophysical properties of both enveloped virus and cell membranes must be favourable for successful fusion and entry of the virus into its host. Characterising these properties in cells and virions is critical for understanding and manipulating target cell susceptibility to infection, as well as blocking infection by cell-autonomous antiviral proteins. To characterise such properties, we developed imaging assays multiplexing genetically-encoded biosensors concomitant with single virus ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Cellular Imaging
Oxford college:
Magdalen College
Role:
Author

Contributors

Institution:
National Cancer Institute
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Research group:
Cellular Imaging
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Examiner
Institution:
King's College London
Role:
Examiner
More from this funder
Name:
National Institutes of Health
Funder identifier:
http://dx.doi.org/10.13039/100000002
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
Deposit date:
2021-04-26

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