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Biochemical and functional characterization of the RNA binding protein SAF-A/hnRNP U and investigation of its potential role in mammalian X chromosome inactivation

Abstract:

X chromosome inactivation (XCI) is an important mechanism for gene dosage compensation between XY males and XX females during early embryonic development of eutherian mammals. The major regulator of XCI is the long non-coding RNA (lncRNA) X inactive specific transcript (Xist). Xist RNA is believed to recruit epigenetic modifiers and initiate a silencing cascade that alters the chromatin structure and culminates in the transcriptional repression of most genes at the inactive X chromosome (X...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
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Name:
Stiftung der Deutschen Wirtschaft
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:6cb30bda-160e-4384-8e69-6f9c41847cb6
Deposit date:
2015-11-01

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