Targeted modulation of cardiac energetics via the creatine kinase system

Thesis

There is a large body of clinical and experimental evidence linking heart disease with impairment of myocardial energetics, particularly the creatine kinase (CK) system. The goal of the experiments described in this thesis was to develop and study models of increased CK phosphotransfer, by overexpressing the CK isoenzymes and/or augmenting intracellular creatine stores.

Pilot experiments were performed in cultured cells, which were used to (a) study the effects of CK overexpression ...

Expand abstract

Authors: Ostrowski, F

• Alternative title: Novel targets for cardioprotective therapy
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: Myocardial energetics; Creatine kinase; Mitochondrial permeability transition pore; Ischemia/reperfusion
• Subjects: Cardiovascular system