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Thesis

Targeted modulation of cardiac energetics via the creatine kinase system

Alternative title:
Novel targets for cardioprotective therapy
Abstract:

There is a large body of clinical and experimental evidence linking heart disease with impairment of myocardial energetics, particularly the creatine kinase (CK) system. The goal of the experiments described in this thesis was to develop and study models of increased CK phosphotransfer, by overexpressing the CK isoenzymes and/or augmenting intracellular creatine stores.

Pilot experiments were performed in cultured cells, which were used to (a) study the effects of CK overexpression ...

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
British Heart Foundation More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:6c5e7c70-07f0-4a14-ba01-d16e9e8c0d1c
Deposit date:
2018-04-11

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