Thesis
Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
- Abstract:
-
Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca2+) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown studies have implicated TPCs in fundamental cellular processes, including secretion, of insulin in pancreatic islets, and differentiation, of skeletal myoblasts and osteoclasts.
Investigations of Tpcn1 ...
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Authors
Contributors
+ Parrington, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
- Publication date:
- 2012
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- UUID:
-
uuid:6c0b970d-6133-4752-987a-e21f6e2dc69c
- Local pid:
-
ora:8237
- Deposit date:
-
2014-03-21
- ARK identifier:
Terms of use
- Copyright holder:
- Ruth Tunn
- Copyright date:
- 2012
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