Thesis
Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function
- Abstract:
-
Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca2+) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown studies have implicated TPCs in fundamental cellular processes, including secretion, of insulin in pancreatic islets, and differentiation, of skeletal myoblasts and osteoclasts.
Investigations of Tpcn1 ...
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Funding
Bibliographic Details
- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- URN:
-
uuid:6c0b970d-6133-4752-987a-e21f6e2dc69c
- Local pid:
- ora:8237
Item Description
- Language:
- English
- Keywords:
- Subjects:
Terms of use
- Copyright holder:
- Ruth Elizabeth Tunn
- Copyright date:
- 2012
- Notes:
- This thesis is not currently available in ORA
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