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Thesis

Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function

Abstract:

Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca2+) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown studies have implicated TPCs in fundamental cellular processes, including secretion, of insulin in pancreatic islets, and differentiation, of skeletal myoblasts and osteoclasts.

Investigations of Tpcn1 ...

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Institution:
University of Oxford
Oxford college:
Worcester College
Department:
Medical Sciences Division - Pharmacology

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Role:
Supervisor
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Funding agency for:
Ruth Elizabeth Tunn
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:6c0b970d-6133-4752-987a-e21f6e2dc69c
Local pid:
ora:8237

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