Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function

Ruth Elizabeth Tunn

Abstract:

Two-pore channels (TPCs, gene name Tpcn) have recently been identified as endolysosomal cation channels modulated by the potent calcium (Ca²⁺) releasing messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Gene knockout (KO) and RNA knockdown studies have implicated TPCs in fundamental cellular processes, including secretion, of insulin in pancreatic islets, and differentiation, of skeletal myoblasts and osteoclasts.

Investigations of Tpcn1 ...

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APA Style

Tunn, R. E. (2012). Expression of two-pore channels in mammalian primary cells and tissues, and their role in adipose tissue formation and function [PhD thesis].

MLA Style

Tunn, Ruth Elizabeth. Expression of Two-Pore Channels in Mammalian Primary Cells and Tissues, and Their Role in Adipose Tissue Formation and Function. 2012.

Chicago Style

Tunn, Ruth Elizabeth. 2012. “Expression of Two-Pore Channels in Mammalian Primary Cells and Tissues, and Their Role in Adipose Tissue Formation and Function.” PhD thesis.
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