Towards the total synthesis of pectenotoxin-4

Thesis

Chapter 1: Introduction This chapter provides the background of the pectenotoxins (PTX), which includes details of their isolation, structure, and biological activity. Subsequently, the total syntheses of PTX-4 by Evans and of PTX-2 by Fujiwara are discussed. Finally, past efforts of the Donohoe group towards the synthesis of PTX-4 are summarised.
Chapter 2: Synthesis of the ABC fragment This chapter details the retrosynthesis and forward synthesis of the C1–C16 ABC fragment of PTX-...

Expand abstract

Authors: Kwok, T

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: osmium; oxidative cyclisation; natural product synthesis; total synthesis
• Subjects: Total Synthesis; Organic Chemistry