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Exploring the mechanisms responsible for energetic dysfunction within the type 2 diabetic heart

Abstract:

Cardiovascular disease accounts for 70% of mortality within type 2 diabetic (T2D) patients. Energetic dysfunction is apparent within the T2D heart, presenting as a decreased phosphocreatine/adenosine triphosphate (PCr/ATP) ratio. This pathophysiology is an independent predictor for mortality risk within the setting of heart failure. While most clinical measurements of cardiac PCr/ATP ratios within T2D patients display a reduced PCr/ATP ratio some disagree, showing no defect. Emerging work ...

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Division:
MSD
Department:
English Faculty
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:6bc35fdf-4d66-4863-b3ab-5c707accbc59
Deposit date:
2020-01-11

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