Thesis
Investigating selective neuronal vulnerability in Alzheimer’s and Parkinson’s disease with induced pluripotent stem cells
- Abstract:
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Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) are enormous, growing, global challenges. However, owing to long prodromal periods, disease complexity, and the inaccessibility of the brain, their causes remain elusive. Nevertheless, the protein aggregation and cell loss which are the cardinal features of these diseases occur with a highly stereotyped and well-defined spatiotemporal progression, where only some cell populations are susceptible, while...
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- Files:
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(Preview, Dissemination version, pdf, 104.4MB, Terms of use)
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Authors
Contributors
+ Wade-Martins, R
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
+ Bengoa-Vergniory, N
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Physiology Anatomy and Genetics
- Role:
- Supervisor
+ Akerman, C
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Pharmacology
- Role:
- Supervisor
+ Cader, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- Clinical Neurosciences
- Role:
- Examiner
- ORCID:
- 0000-0002-6952-406X
+ Wray, S
- Role:
- Examiner
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
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English
- Keywords:
- Subjects:
- Pubs id:
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2268814
- Local pid:
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pubs:2268814
- Deposit date:
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2025-07-08
- ARK identifier:
Terms of use
- Copyright holder:
- Ajantha Abey
- Copyright date:
- 2024
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