Thesis
NMR spectroscopy studies of enzyme function and inhibition
- Abstract:
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The work described in this Thesis focuses on the application of NMR spectroscopy methods in understanding the function and inhibition of two protein systems; these are γ-butyrobetaine hydroxylase (BBOX) and the bacterial potassium ion efflux (Kef) system. BBOX belongs to the super family of enzymes called the 2- oxoglutarate (2OG) and FeII dependent oxygenase and is involved in the biosynthesis of L-carnitine in humans and other prokaryotes. BBOX is a current drug target for...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Subjects:
- UUID:
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uuid:698d69c7-d4f1-4bc7-bf0b-3b9e7fb3a4fe
- Deposit date:
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2016-06-03
Terms of use
- Copyright holder:
- Khan, A
- Copyright date:
- 2016
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