Journal article
Multicopy plasmids potentiate the evolution of antibiotic resistance in bacteria
- Abstract:
-
Plasmids are thought to play a key role in bacterial evolution by acting as vehicles for horizontal gene transfer, but the role of plasmids as catalysts of gene evolution remains unexplored. We challenged populations of E. coli carrying blaTEM-1 β- lactamase gene on either the chromosome or a multicopy plasmid (19/cell) with increasing concentrations of ceftazidime. The plasmid accelerated resistance evolution by increasing the rate of appearance of novel TEM-1 mutations conferring resistance...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ Instituto de Salud Carlos III
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Funding agency for:
San Millan, A
Grant:
Miguel Servet Fellowship MS15/00012
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Ecology and Evolution Journal website
- Volume:
- 1
- Pages:
- 0010
- Publication date:
- 2016-11-07
- Acceptance date:
- 2016-08-31
- DOI:
- EISSN:
-
2397-334X
Item Description
- Pubs id:
-
pubs:641887
- UUID:
-
uuid:68a649fb-b18b-4a72-b24e-c26f1ff5bfa1
- Local pid:
- pubs:641887
- Source identifiers:
-
641887
- Deposit date:
- 2016-09-09
Terms of use
- Copyright holder:
- San Millan et al
- Copyright date:
- 2016
- Notes:
-
© 2016 Author(s); published by Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: [10.1038/s41559-016-0010]
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