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Thesis

Probing environmental effects on gas-phase protein structure

Abstract:

Growth in the use of mass spectrometry as an analytical tool for studying protein structure and functionality has posed questions regarding correlation of native structures and observed gas-phase conformations for proteins. This thesis explores the relationship between the solution-phase and gas-phase structures of soluble proteins, and investigates the effect of the lipid environment on membrane proteins.

To assess gas-phase structure, ion-mobility mass spectrometry was used to mea...

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English

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