A ketone ester for diabetes mellitus

Thesis

Various studies have reported that type 2 diabetes mellitus (T2DM) may be reversed by following a ketogenic diet, although it is not clear if this is due to carbohydrate restriction or a consequence of elevating the concentration of ketone bodies in the blood (ketosis). A recently developed ketone ester (KE) drink, which elevates human circulating D-βhydroxybutyrate (βHB) levels by ~3 mM within minutes, allows to isolate the effects of ketosis and carbohydrate restriction.

Th...

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Authors: Soto mota, LA

• DOI: 10.5287/ora-nz2gaamd5
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: ketone bodies; ester; Beta-hydroxybutyrate; ketosis; diabetes mellitus
• Subjects: Biochemistry; Human metabolism; Physiology; Diabetes