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BCR repertoire sequencing: Different patterns of B-cell activation after two Meningococcal vaccines

Abstract:

Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/icb.2015.57

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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, College Only, Magdalen College
Role:
Author
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Biotechnology and Biological Sciences Research Council More from this funder
Jenner Institute More from this funder
Oxford Martin School More from this funder
GlaxoSmithKline More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
93
Issue:
10
Pages:
885-895
Publication date:
2015-06-05
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
URN:
uuid:6786362d-c329-4ca8-9cf8-84c8990f9789
Source identifiers:
579439
Local pid:
pubs:579439

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