Journal article
BCR repertoire sequencing: Different patterns of B-cell activation after two Meningococcal vaccines
- Abstract:
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Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, vnd.openxmlformats-officedocument, 1.6MB)
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- Publisher copy:
- 10.1038/icb.2015.57
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Authors
Funding
Biotechnology and Biological Sciences Research Council
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Medical Research Council
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Oxford Martin School
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Jenner Institute
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Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Immunology and Cell Biology Journal website
- Volume:
- 93
- Issue:
- 10
- Pages:
- 885-895
- Publication date:
- 2015-06-01
- Acceptance date:
- 2015-05-11
- DOI:
- EISSN:
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1440-1711
- ISSN:
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0818-9641
- Source identifiers:
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579439
Item Description
- Pubs id:
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pubs:579439
- UUID:
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uuid:6786362d-c329-4ca8-9cf8-84c8990f9789
- Local pid:
- pubs:579439
- Deposit date:
- 2016-03-01
Terms of use
- Copyright holder:
- Australasian Society for Immunology
- Copyright date:
- 2015
- Notes:
- © 2015 Australasian Society for Immunology Inc. All rights reserved 0818-9641/15
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