Journal article icon

Journal article

BCR repertoire sequencing: Different patterns of B-cell activation after two Meningococcal vaccines

Abstract:

Next-generation sequencing was used to investigate the B cell receptor heavy chain transcript repertoire of different B cell subsets (naïve, marginal zone, IgM memory and IgG memory) at baseline, and of plasma cells 7 days following administration of serogroup ACWY meningococcal polysaccharide and protein-polysaccharide conjugate vaccines. Baseline B cell subsets could be distinguished from each other using a small number of repertoire properties (clonality, mutation from germ-line and comple...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/icb.2015.57

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Magdalen College
Role:
Author
Expand authors...
Biotechnology and Biological Sciences Research Council More from this funder
Medical Research Council More from this funder
Oxford Martin School More from this funder
Jenner Institute More from this funder
Expand funders...
Publisher:
Nature Publishing Group Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
93
Issue:
10
Pages:
885-895
Publication date:
2015-06-01
Acceptance date:
2015-05-11
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Source identifiers:
579439
Pubs id:
pubs:579439
UUID:
uuid:6786362d-c329-4ca8-9cf8-84c8990f9789
Local pid:
pubs:579439
Deposit date:
2016-03-01

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP