Journal article
DNA hairpins primarily promote duplex melting rather than inhibiting hybridization
- Abstract:
-
The effect of secondary structure on DNA duplex formation is poorly understood. Using oxDNA, a nucleotide level coarse-grainedmodel of DNA, we study how hairpins influence the rate and reaction pathways of DNA hybridzation. We compare to experimental systems studied by Gao et al. and find that 3-base pair hairpins reduce the hybridization rate by a factor of 2, and 4-base pair hairpins by a factor of 10, compared to DNA with limited secondary structure, which is in good agreement with expe...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
University College, Oxford
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Bibliographic Details
- Journal:
- Nucleic Acids Research
- Volume:
- 43
- Issue:
- 13
- Pages:
- 6181-6190
- Publication date:
- 2014-08-19
- DOI:
- EISSN:
-
1362-4962
- ISSN:
-
0305-1048
Item Description
- Keywords:
- Pubs id:
-
pubs:482452
- UUID:
-
uuid:6753b187-c718-4f7d-9c71-7c77a8eb20c7
- Local pid:
- pubs:482452
- Source identifiers:
-
482452
- Deposit date:
- 2014-09-14
Terms of use
- Copyright holder:
- Oxford University Press
- Copyright date:
- 2014
- Notes:
- © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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